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Pendahuluan: COVID-19 berkembang menjadi pandemik global dan sampai saat ini belum ditemukan terapi yang definitif. Mortalitas COVID-19 relatif tinggi, terutama pada pasien yang memiliki komorbid. Terapi plasma konvalesen yang sudah banyak dilakukan belum diakui secara universal mampu meningkatkan kesembuah pasien COVID-19. Tujuan: Penelitian ini bertujuan mengetahui efikasi terapi plasma konvalesen pada pasien COVID-19. Metode: Desain peneitian adalah systematic Review dan Meta Analisa. Data diperoleh dari database jurnal elektronik PubMed, Cochrane Library, ProQuest, SpringerLink, ScienceDirect, Scopus, dan Google Scholar dengan Medical Subject Heading (Mesh) “Effication Plasma Convalescent Therapy, SARS CoV-2”. Data dianalisis menggunakan pedoman PRISMA. Hasil: Hasil penelitian : 1) Tidak ada perbedaan risiko atau tingkat kematian pasien Covid-19 yang diberikan terapi plasma konvalesen dengan yang diberikan terapi standar (OR:1,004;CI; 0,817 - 1,234;p= 0,970), 2) Tingkat kesembuhan pasien COVID-19 yang diberikan terapi plasma konvalesen tidak berbeda dengan yang diberikan terapi standar (OR:0,996;CI:0,810 – 1,224;p=0,970). Kesimpulan: terapi plasma konvalesen tidak memberikan efikasi yang cukup baik dalam proses penyembuhan pasien COVID-19 dengan gejala sedang sampai berat.

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COVID - 19 Efikasi Terapi Plasma Konvalesen

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