Main Article Content
Abstract
Introduction: COVID-19 has developed into a global pandemic and until now no definitive therapy has been found. COVID-19 mortality is relatively high, especially in patients who have comorbidities. Convalescent plasma therapy, which has been widely used, has not been universally recognized as being able to improve the recovery of COVID-19 patients. Objective: This study aims to determine the efficacy of convalescent plasma therapy in COVID-19 patients. Methods: The research design is a systematic review and meta analysis. Data were obtained from the electronic journal database PubMed, Cochrane Library, ProQuest, SpringerLink, ScienceDirect, Scopus, and Google Scholar with Medical Subject Heading (Mesh) "Effication Plasma Convalescent Therapy, SARS CoV-2". Data were analyzed using PRISMA guidelines. Result: The results of the study: 1) There was no difference in the risk or mortality rate of Covid-19 patients given convalescent plasma therapy with those given standard therapy (OR: 1.004; CI; 0.817 - 1.234; p = 0.970), 2) The recovery rate of COVID-19 patients given convalescent plasma therapy did not differ from those given standard therapy (OR: 0.996; CI: 0.810 – 1.224; p = 0.970). Conclusion: convalescent plasma therapy did not provide sufficient efficacy in the healing process of COVID-19 patients with moderate to severe symptoms.
Keywords
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References
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References
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Agarwal, A., Mukherjee, A., Kumar, G., Chatterjee, P., & Bhatnagar, T. (2020). Convalescent plasma in the management of moderate covid-19 in adults in India : open label phase II multicentre randomised controlled trial ( PLACID Trial ). 1–10. https://doi.org/10.1136/bmj.m3939
Alqahtani, M., Abdulrahman, A., Almadani, A., Alali, S. Y., Mahmood, A., Zamrooni, A., Hejab, A. H., Conroy, R. M., Wasif, P., Otoom, S., Atkin, S. L., & Abduljalil, M. (2021). Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID ‑ 19 disease. Scientific Reports, 1–8. https://doi.org/10.1038/s41598-021-89444-5
Bank Indonesia. (2020). Krisis Kemanusiaan COVID-19 dan Implikasinya pada Tatanan Perekonomian Global. 2020, 20. https://www.bi.go.id/id/publikasi/laporan/Documents/3_LPI2020_BAB1.pdf
Berg, K. Van Den, Glatt, T. N., Vermeulen, M., Little, F., Swanevelder, R., Barrett, C., Court, R., Bremer, M., Nyoni, C., Swarts, A., Mmenu, C., Crede, T., Kritzinger, G., & Naude, J. (2022). Convalescent plasma in the treatment of moderate to severe COVID ‑ 19 pneumonia : a randomized controlled trial ( PROTECT ‑ Patient Trial ). Scientific Reports, 1–11. https://doi.org/10.1038/s41598-022-06221-8
Callum, J., Jamula, E., Cook, R., Heddle, N. M., Tinmouth, A., Zeller, M. P., Amorim, L., Loftsgard, K. C., Carl, R., Cushing, M. M., Daneman, N., Devine, D. V, Dumaresq, J., Fergusson, D. A., Gabe, C., Glesby, M. J., Li, N., Liu, Y., Mcgeer, A., … Arnold, D. M. (2021). Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. 27(November). https://doi.org/10.1038/s41591-021-01488-2
Diyono, & Kristanto, B. (2021). Faktor Comorbid Covid-19 di Indonesia Scopyng Review. Jurnal Ilmu Kesehatan, 9(1), 51–59.
Donnell, M. R. O., Grinsztejn, B., Cummings, M. J., Justman, J. E., Lamb, M. R., Eckhardt, C. M., Philip, N. M., Cheung, Y. K., Gupta, V., João, E., Pilotto, J. H., Diniz, M. P., Cardoso, S. W., Abrams, D., Rajagopalan, K. N., Borden, S. E., Wolf, A., Sidi, L. C., Vizzoni, A., … Schwartz, J. (2021). A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19. 2019(1), 1–9.
Holm, K., Lundgren, M. N., Kragh, J. K., Ljungquist, O., Böttiger, B., Wikén, C., Öberg, J., Fernström, N., Rosendal, E., Överby, A. K., Byström, J. W., Forsell, M., Olsson, M. L., & Rasmussen, M. (2021). Convalescence plasma treatment of COVID ‑ 19 : results from a prematurely terminated randomized controlled open ‑ label study in Southern Sweden. BMC Research Notes, 1–5. https://doi.org/10.1186/s13104-021-05847-7
Ika. (2020). Mengenal Terapi Konvalesen Sebagai Alternatif Pengobatan Covid-19. Universitas Gajah Mada, 2. https://ugm.ac.id/id/berita/19645-mengenal-terapi-konvalesen-sebagai-alternatif-pengobatan-covid-19
Indraswara, Y. (2021). Plasma konvalesen untuk COVID-19. OSF Preprints, 1(19), 3. https://osf.io/s25m3/
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Kemdikbud. (2017). Kamus Besar Bahasa Indonesia. https://kbbi.web.id/mitra.
Klassen, S. A., Senefeld, J. W., Johnson, P. W., Carter, R. E., Wiggins, C. C., Shoham, S., Grossman, B. J., Henderson, J. P., Musser, J., Salazar, E., Hartman, W. R., Bouvier, N. M., Liu, S. T. H., Pirofski, L. anne, Baker, S. E., van Helmond, N., Wright, R. S., Fairweather, D. L., Bruno, K. A., … Joyner, M. J. (2021). The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis. Mayo Clinic Proceedings, 96(5), 1262–1275. https://doi.org/10.1016/j.mayocp.2021.02.008
Li, L., Zhang, W., Hu, Y., Tong, X., Zheng, S., Yang, J., & Kong, Y. (2020). Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19 A Randomized Clinical Trial. 324(5), 460–470. https://doi.org/10.1001/jama.2020.10044
Liege, U. of. (2020). Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation. ClinicalTrials.Gov.
Mardian, Y. (2020). Uji Klinis Pemberian Plasma Konvalesen Sebagai Terapi Tambahan Corona Virus Disease 19 (COVID-19)-PLASENTER. Angewandte Chemie International Edition, 6(11), 951–952., 1.
Maulana, M. S. (2020). Efektivitas Efikasi Pemberian Terapi Konvalesen Plasma Pada Pasien Covid-19 : Evidence Based Case Report. Jurnal Kedokteran Dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 7(3), 7–14. https://doi.org/10.32539/jkk.v7i3.12297
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PMI. (2021). Procurement Convalescent Plasma for Covid-19 in Indonesia Red Cross. Webinar Pds Patklin Pmi Roche. https://www.pdspatklin.or.id/assets/files/pdspatklin_2021_04_18_20_55_26.pdf
Ratnadi, P. C., & Sujana, I. B. G. (2017). Prinsip Dasar Farmakologi. Medical Education, Pp. 1-86. https://simdos.unud.ac.id/uploads/file_penelitian_1_dir/f7b9df04ff99e9d55d73e117e78f7d61.pdf
Rejeki, M. S., Sarnadi, N., Wihastuti, R., Fazharyasti, V., Samin, W. Y., Yudhaputri, F. A., Johar, E., Nurainy, N., Bachtiar, N. S., & Muljono, D. H. (2021). Convalescent plasma therapy in patients with moderate-to-severe COVID-19: A study from Indonesia for clinical research in low- and middle-income countries. EClinicalMedicine, 36, 100931. https://doi.org/10.1016/j.eclinm.2021.100931
Sekine, L., Arns, B., Fabro, B. R., Cipolatt, M. M., Machado, R. R. G., Durigon, E. L., Parolo, E., Pellegrini, J. A. S., Viana, M. V, Schwarz, P., Lisboa, T. C., Dora, J. M. S., Portich, J. P., Paz, A. A., Silla, L., Balsan, A. M., Schirmer, F., Franz, J. P. M., Luciana, M., … Rosa, R. G. (2022). Convalescent plasma for COVID-19 in hospitalised patients : an open-label , randomised clinical trial. April 2021. https://doi.org/10.1183/13993003.01471-2021
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Sola, C., Ramos-martínez, A., Muñez-rubio, E., Ruiz-antorán, B., Molina, R. M. De, Torres, F., Fernández-cruz, A., Calderón-parra, J., Payares-herrera, C., Santiago, A. D. De, Romera-martínez, I., Pintos, I., Lora-tamayo, J., Mancheño-losa, M., Paciello, M. L., Vidán-estévez, J., Nuñez-orantos, M. J., Saez-serrano, M. I., Porras-leal, M. L., … Rubio-batllés, M. (2021). A multicenter randomized open-label clinical trial for convalescent plasma in patients hospitalized with COVID-19 pneumonia. 131(20), 1–10.
Susilo, A., Rumende, C. M., Pitoyo, C. W., Santoso, W. D., Yulianti, M., Herikurniawan, H., Sinto, R., Singh, G., Nainggolan, L., Nelwan, E. J., Chen, L. K., Widhani, A., Wijaya, E., Wicaksana, B., Maksum, M., Annisa, F., Jasirwan, C. O. M., & Yunihastuti, E. (2020). Coronavirus Disease 2019: Tinjauan Literatur Terkini. Jurnal Penyakit Dalam Indonesia, 7(1), 45. https://doi.org/10.7454/jpdi.v7i1.415
Unhale, S. S., Ansar, Q. B., Sanap, S., Thakhre, S., & Wadatkar, S. (2020). a Review on Corona Virus ( Covid-19 ). World Journal of Pharmaceutical, 6(4), 109–115.
Vegivinti, C. T. R., Pederson, J. M., Saravu, K., Gupta, N., Evanson, K. W., Kamrowski, S., Schmidt, M., Barrett, A., Trent, H., Dibas, M., Reierson, N. L., Mikoff, N., Pisipati, S., Joseph, B. A., Selvan, P. T., Dmytriw, A. A., Pulakurthi, Y. S., Keesari, P. R., Sriram, V., … Hassan, A. E. (2021). Efficacy of convalescent plasma therapy for COVID-19: A systematic review and meta-analysis. Journal of Clinical Apheresis, 36(3), 470–482. https://doi.org/10.1002/jca.21881
Yang, J., Zheng, Y., Gou, X., Pu, K., Chen, Z., Guo, Q., Ji, R., Wang, H., Wang, Y., & Zhou, Y. (2020). Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis. International Journal of Infectious Diseases, 94, 91–95. https://doi.org/10.1016/j.ijid.2020.03.017.